Metabolic Health
Gut Microbiome Composition Predicts Response to Personalized Probiotic Interventions in Metabolic Syndrome
Santos M, Costa A, Ferreira J, Silva P
Nature Metabolism
January 2026
45 citations
This longitudinal study investigated the relationship between baseline gut microbiome composition and clinical outcomes following personalized probiotic interventions in 250 patients with metabolic syndrome. Using next-generation sequencing and machine learning algorithms, we identified specific microbial signatures that predicted treatment response with 87% accuracy. Our findings suggest that microbiome-guided personalization significantly improves therapeutic efficacy compared to standard probiotic formulations.
DOI:
10.1038/s42255-024-00123-4
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