Dermatology
Akkermansia muciniphila Supplementation Improves Skin Barrier Function Through Gut-Skin Axis Modulation
Ferreira J, Santos M, Oliveira R
Journal of Investigative Dermatology
December 2025
62 citations
We conducted a randomized, double-blind, placebo-controlled trial examining the effects of Akkermansia muciniphila supplementation on skin barrier function in 180 adults with compromised skin health. Results demonstrated significant improvements in transepidermal water loss, skin hydration, and inflammatory markers after 12 weeks. Mechanistic studies revealed enhanced production of short-chain fatty acids and modulation of systemic inflammation as key mediators of the gut-skin axis.
DOI:
10.1016/j.jid.2023.11.034
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