Inflammation Marker Package: Faecal Zonulin & Secretory IgA

Inflammation Marker Package: Faecal Zonulin & Secretory IgA

Enzyme-linked immunosorbent assay (ELISA)

A stool-based inflammation marker package that assesses intestinal permeability and mucosal immune activity by measuring faecal zonulin and secretory IgA, helping support evaluation of gut barrier integrity, immune response, and gastrointestinal health.

Turnaround 4-5 weeks after sample receipt
Sample Type Stool sample
Method ELISA
79.00 per test kit
Quantity
ISO 9001:2015 Certified
GDPR Compliant
Free Shipping

What's Included

x1 faeces catcher
x1 Danastool microbiome collection kit
x1 absorbent bag
x1 plastic safety bag
x1 DHL return bag with prepaid Waybill
Instruction leaflet (sample collection & data processing)

Full Description

This package provides a combined assessment of gut permeability and mucosal immune function by measuring zonulin and secretory IgA in stool (faeces). Zonulin is involved in the regulation of intestinal tight junctions, and increased levels are associated with increased intestinal permeability, commonly referred to as “leaky gut”. Secretory IgA is the primary immunoglobulin found in mucosal secretions, including stool, and supports intestinal immune defence and barrier function.

The test may be useful for evaluating immunological activity in the gastrointestinal tract, monitoring intestinal infections or gut inflammation, and tracking treatment progress in inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. Elevated secretory IgA may suggest an active mucosal immune response, while decreased levels may indicate reduced mucosal immunity, response to treatment, or worsening barrier-related status. Results should be interpreted together with symptoms, medical history, and other relevant investigations.

The Process: from purchase to results

  1. Order your test – The kit is delivered to your door. Once you purchase your test kit, you will receive an email with a link to the Customer Guide. You will need to log in (using the credentials you created upon purchasing the kit), to access the Customer guide.
  2. Fill in the form – Submit the online consent form, medical history questionnaire, and sample collection date/s.
  3. Collect your samples – Follow the step-by-step instructions for stool sample collection.
  4. Send it back – Return your sample using the mailing bag with prepaid return shipping label.
  5. Receive your report – Get your faecal zonulin and secretory IgA results within 4-5 weeks of sample receipt.

Optional Add-Ons/Related Tests

Intestinal Inflammation & Stool Acidity

Gut Microbiome Testing

Stool Parasite Testing

Nutritional Consultation

Key Features

  • Measures faecal zonulin, a marker linked to intestinal tight junction regulation and gut permeability.
  • Measures secretory IgA, the main immunoglobulin involved in mucosal immune defence and intestinal barrier function.
  • Supports assessment of gastrointestinal immune activity, gut inflammation, and treatment monitoring when interpreted with clinical context.

Frequently Asked Questions

Why should I get this test?
This test provides supportive information about gut permeability and mucosal immune activity. It may be useful if you have digestive symptoms, suspected gut inflammation, recurrent intestinal infections, inflammatory bowel disease follow-up, or if you want additional markers to complement gut microbiome results.
How do I prepare for sample collection?
Follow the stool collection instructions provided with the kit. Samples should be collected cleanly and should not be contaminated with urine, toilet water, disinfectants, or cleaning products. Include your current medications and relevant symptoms in the questionnaire.
What is included in the report?
Your report includes fecal zonulin and secretory IgA results, with interpretation to support discussion with your healthcare provider.
How do I interpret the results?
Results should be interpreted by your doctor or another qualified healthcare professional. Higher zonulin may be associated with increased intestinal permeability, while secretory IgA reflects mucosal immune activity and should be considered alongside symptoms, stool microbiome findings, inflammatory markers, treatment history, and other clinical information.
What does IVD mean?
In vitro diagnostics (IVD) tests are medical diagnostic tests that are used for the diagnosis, monitoring, or treatment of diseases or medical conditions in humans. In contrast to other, research use only (RUO) tests, IVD tests are regulated by governmental agencies and are required to meet certain performance standards before they can be marketed and sold to the public. This assay consists of two IVD tests.
Do you ship worldwide?
This service is currently available only for customers living in the EU.
What complementary tests or services should I consider?
Optional add-ons that may provide you or your healthcare provider with more in-depth information include:

Calprotectin & Faecal pH

Testing for intestinal inflammation and stool acidity.

Gut Microbiota Testing

Comprehensive assessment of gut microorganisms together with personalised dietary recommendations.

Parasite Testing

Real‑time PCR detection of common intestinal parasites (Cryptosporidium, Giardia lamblia and/or Entamoeba histolytica)